FIGURE

Fig 1

ID

ZDB-FIG-190723-1569

Publication

Oppel et al., 2019 - Loss of atrx cooperates with p53-deficiency to promote the development of sarcomas and other malignancies

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Fig 1

CRISPR/Cas9-mediated knockout of <italic>atrx</italic> in zebrafish germline.

(A) The wildtype (WT) Atrx protein consists of 2013 amino acids (aa). Targeting of the atrx coding sequence with CRISPR/Cas9 resulted in truncation of Atrx before its functional domains and confers a loss of function; numbers indicate the underlying genetic alterations, e.g., +4 = insertion of 4 bases. (B)atrx-/- embryos show developmental abnormalities and die within 18 days post fertilization (dpf); sibling includes both atrx+/- and atrx+/+ embryos.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	atrx^zdf36/zdf36 (AB)
Observed In:	whole organism
Stage Range:	Days 7-13 to Days 14-20

Phenotype Detail

Acknowledgments

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