Fig. 5
- ID
- ZDB-FIG-190604-31
- Publication
- Jung et al., 2018 - The Ancient Origins of Neural Substrates for Land Walking
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LMC Neurons Are Present in Multiple Species of Aquatic Vertebrates (A) Expression of MN determinants in the small-spotted catshark, Scyliorhinus canicula, at st31. Foxp1+ MNs are detected at fin levels but are absent in inter-fin (“Th”) and tail levels. Lhx3+ MMC-like neurons are present at all levels and lack Foxp1. (B) Retrograde labeling of MNs after HRP injection into the pectoral fin in Scyliorhinus. Foxp1+ MNs co-label with HRP. (C) In situ hybridization showing expression of MN markers and Hox genes in Callorhinchus milii at st31. Foxp1 is detected at fin levels and also at inter-fin and tail levels, possibly reflecting spinal INs. Hoxc6 is expressed at pectoral levels, Hoxc9 at inter-fin levels, and Hoxc10 at pelvic fin levels. Differences in relative image magnification are shown. (D–G) Expression of MN determinants in zebrafish. (D) Dorsal view of a 72-hpf Mnx1::GFP embryo showing expression of Foxp1 at pectoral levels. GFP also labels projections to the pectoral (Pec) fin. Foxp1 is expressed in INs at more caudal segments. (E) Lateral view showing coexpression of GFP in a subset of Foxp1+neurons. (F) Lateral view of 48-hpf embryo showing Foxp1 and Isl1 expression. (G) Transverse sections showing that Foxp1+ neurons lack Lhx3. (H) Simplified chordate phylogeny indicating the presence of a limb/fin innervation program in the common ancestor to skates and tetrapods. |
Reprinted from Cell, 172, Jung, H., Baek, M., D'Elia, K.P., Boisvert, C., Currie, P.D., Tay, B.H., Venkatesh, B., Brown, S.M., Heguy, A., Schoppik, D., Dasen, J.S., The Ancient Origins of Neural Substrates for Land Walking, 667-682.e15, Copyright (2018) with permission from Elsevier. Full text @ Cell