ZFIN Figure: Sorrells et al., 2018, Fig. 2

ZFIN ID: ZDB-FIG-181228-1

ZFIN ID: ZDB-FIG-181228-1

Sorrells et al., 2018 - Spliceosomal components protect embryonic neurons from R-loop-mediated DNA damage and apoptosis. Disease models & mechanisms 11(2) Full text @ Dis. Model. Mech.

ADDITIONAL FIGURES

EXPRESSION / LABELING:

Gene:	tp53
Antibody:	Ab2-h2afx
Fish:	sf3b1^{hi3394aTg/hi3394aTg} (AB) sfpq^{hi1779Tg/hi1779Tg} (AB) yju2^{zd1000/zd1000} (AB) hspa8^hi138Tg (AB) plrg1^hi3174aTg (AB) tp53^zdf1/zdf1; plrg1^hi3174aTg (AB) tp53^zdf1/zdf1; sf3b1^{hi3394aTg/hi3394aTg} (AB) tp53^zdf1/zdf1; yju2^{zd1000/zd1000} (AB)
Anatomical Term:	whole organism
Stage:	Prim-15

PHENOTYPE:

Fish:	sf3b1^{hi3394aTg/hi3394aTg} (AB) sfpq^{hi1779Tg/hi1779Tg} (AB) yju2^{zd1000/zd1000} (AB) hspa8^hi138Tg (AB) plrg1^hi3174aTg (AB) tp53^zdf1/zdf1; plrg1^hi3174aTg (AB) tp53^zdf1/zdf1; sf3b1^{hi3394aTg/hi3394aTg} (AB) tp53^zdf1/zdf1; yju2^{zd1000/zd1000} (AB)
Observed In:	whole organism
Stage:	Prim-15

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Gene Expression Details

Gene	Fish	Conditions	Stage	Anatomy	Assay
tp53	hspa8^hi138Tg (AB)	standard conditions	Prim-15	whole organism	WB
	plrg1^hi3174aTg (AB)	standard conditions	Prim-15	whole organism	WB
	sf3b1^{hi3394aTg/hi3394aTg} (AB)	standard conditions	Prim-15	whole organism	WB
	yju2^{zd1000/zd1000} (AB)	standard conditions	Prim-15	whole organism	WB

Antibody Labeling Details

Antibody	Assay	Fish	Conditions	Stage	Anatomy
Ab2-h2afx	WB	plrg1^hi3174aTg (AB)	standard conditions	Prim-15	whole organism
	WB	sf3b1^{hi3394aTg/hi3394aTg} (AB)	standard conditions	Prim-15	whole organism
	WB	sfpq^{hi1779Tg/hi1779Tg} (AB)	standard conditions	Prim-15	whole organism
	WB	tp53^zdf1/zdf1; plrg1^hi3174aTg (AB)	standard conditions	Prim-15	whole organism
	WB	tp53^zdf1/zdf1; sf3b1^{hi3394aTg/hi3394aTg} (AB)	standard conditions	Prim-15	whole organism
	WB	tp53^zdf1/zdf1; yju2^{zd1000/zd1000} (AB)	standard conditions	Prim-15	whole organism
	WB	yju2^{zd1000/zd1000} (AB)	standard conditions	Prim-15	whole organism

Phenotype Details

Fish	Conditions	Stage	Phenotype
hspa8^hi138Tg (AB)	standard conditions	Prim-15	whole organism tp53 expression increased amount, abnormal
plrg1^hi3174aTg (AB)	standard conditions	Prim-15	whole organism tp53 expression increased amount, abnormal
		Prim-15	whole organism ab2-h2afx labeling increased amount, abnormal
sf3b1^{hi3394aTg/hi3394aTg} (AB)	standard conditions	Prim-15	whole organism tp53 expression increased amount, abnormal
		Prim-15	whole organism ab2-h2afx labeling increased amount, abnormal
sfpq^{hi1779Tg/hi1779Tg} (AB)	standard conditions	Prim-15	whole organism ab2-h2afx labeling increased amount, abnormal
tp53^zdf1/zdf1; plrg1^hi3174aTg (AB)	standard conditions	Prim-15	whole organism ab2-h2afx labeling increased amount, abnormal
tp53^zdf1/zdf1; sf3b1^{hi3394aTg/hi3394aTg} (AB)	standard conditions	Prim-15	whole organism ab2-h2afx labeling increased amount, abnormal
tp53^zdf1/zdf1; yju2^{zd1000/zd1000} (AB)	standard conditions	Prim-15	whole organism ab2-h2afx labeling increased amount, abnormal
yju2^{zd1000/zd1000} (AB)	standard conditions	Prim-15	whole organism tp53 expression increased amount, abnormal
		Prim-15	whole organism ab2-h2afx labeling increased amount, abnormal

Acknowledgments:
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dis. Model. Mech.