FIGURE

Fig. 6

ID

ZDB-FIG-180828-65

Publication

Tsai et al., 2018 - Small molecule inhibition of RAS/MAPK signaling ameliorates developmental pathologies of Kabuki Syndrome

Other Figures

All Figure Page

Back to All Figure Page

Fig. 6

Treatment with dmDf rescues the defects of stable kmt2d mutant. kmt2d^+/− adults were in-crossed and the embryos were then collected at 1 dpf, 2 dpf and 5 dpf to assess dmDf efficacy. (a) dmDf ameliorates significantly the CE defect in kmt2d^+/− × kmt2d^+/− progeny. (b) Treatment with dmDf increases significantly the brain cell proliferation of kmt2d^+/− × kmt2d^+/− progeny. (c) administration of dmDf appears to ameliorate the differentiation delay in kmt2d^+/− × kmt2d^+/− progeny. (d) dmDf rescues significantly the jaw defect in kmt2d^+/− × kmt2d^+/− progeny. *p < 0.05; **p < 0.01; ***p < 0.001. Error bars show SEM (standard error of the mean).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	kmt2d^{rdu1001/rdu1001}
Condition:	chemical treatment by environment: B-Raf inhibitor
Observed In:	brain cell population proliferation ceratohyal cartilage convergent extension involved in gastrulation mandibular arch skeleton Meckel's cartilage
Stage Range:	Prim-5 to Day 5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Sci. Rep.