FIGURE

Fig. S8

ID

ZDB-FIG-180822-37

Publication

Schultz et al., 2018 - Epigenetic regulators Rbbp4 and Hdac1 are overexpressed in a zebrafish model of RB1 embryonal brain tumor, and are required for neural progenitor survival and proliferation

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Fig. S8

rb1D7/D7 mutant cells in M-phase lack expression of the neuronal differentiation marker HuC/D. A, B High magnification image of phosphohistone-H3 positive nuclei (B, arrows) and HuC/D-positive cells in the tectum of a 5 dpf rb1D7/D7 mutant brain. No overlap is detected between cells expressing HuC/D (C, red) and phosphohistone-H3 (D, green, arrows, dashed outlines). The chromatin in the phosphohistone-H3 positive cells appears highly condensed (E, arrows), consistent with cells in prophase/prometaphase of the cell cycle.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dis. Model. Mech.