ZFIN ID: ZDB-FIG-180709-35
Yao et al., 2017 - Zebrafish cdc6 hypomorphic mutation causes Meier-Gorlin syndrome-like phenotype. Human molecular genetics   26(21):4168-4180 Full text @ Hum. Mol. Genet.
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Genes:
Antibody:
Fish:
Anatomical Terms:
Stage Range: 26+ somites to Prim-5
PHENOTYPE:
Fish:
Observed In:
Stage Range: 20-25 somites to Prim-5

Fig. 3 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
aspm WT standard conditions 26+ somites whole organism RTPCR
Prim-5 whole organism RTPCR
cdc6tsu4305/tsu4305 standard conditions 26+ somites whole organism RTPCR
Prim-5 whole organism RTPCR
cdk1 cdc6tsu4305/tsu4305 standard conditions 26+ somites whole organism WB
Prim-5 whole organism WB
cdk2 cdc6tsu4305/tsu4305 standard conditions 26+ somites whole organism WB
Prim-5 whole organism WB
cenpf WT standard conditions 26+ somites whole organism RTPCR
Prim-5 whole organism RTPCR
cdc6tsu4305/tsu4305 standard conditions 26+ somites whole organism RTPCR
Prim-5 whole organism RTPCR
stag1a WT standard conditions 26+ somites whole organism RTPCR
Prim-5 whole organism RTPCR
cdc6tsu4305/tsu4305 standard conditions 26+ somites whole organism RTPCR
Prim-5 whole organism RTPCR
Antibody Labeling Details
Antibody Assay Fish Conditions Stage Anatomy
Ab2-tuba IHC WT standard conditions Prim-5 spinal cord mitotic spindle
IHC cdc6tsu4305/tsu4305 standard conditions Prim-5 spinal cord mitotic spindle
Phenotype Details
Fish Conditions Stage Phenotype
cdc6tsu4305/tsu4305 standard conditions 20-25 somites mitotic G1 phase decreased occurrence, abnormal
20-25 somites mitotic S phase increased occurrence, abnormal
26+ somites cell population proliferation decreased occurrence, abnormal
26+ somites cell population proliferation disrupted, abnormal
26+ somites mitotic G1 phase decreased occurrence, abnormal
26+ somites mitotic G2/M transition checkpoint decreased occurrence, abnormal
26+ somites mitotic S phase increased occurrence, abnormal
26+ somites whole organism aspm expression decreased amount, abnormal
26+ somites whole organism cdk1 expression increased amount, abnormal
26+ somites whole organism cdk2 expression increased amount, abnormal
26+ somites whole organism cenpf expression decreased amount, abnormal
26+ somites whole organism stag1a expression decreased amount, abnormal
Prim-5 mitotic G1 phase decreased occurrence, abnormal
Prim-5 mitotic G2/M transition checkpoint decreased occurrence, abnormal
Prim-5 mitotic S phase increased occurrence, abnormal
Prim-5 retinal pigmented epithelium nucleus increased area, abnormal
Prim-5 retinal pigmented epithelium nucleus increased size, abnormal
Prim-5 spinal cord mitotic sister chromatid segregation disrupted, abnormal
Prim-5 whole organism aspm expression decreased amount, abnormal
Prim-5 whole organism cdk1 expression increased amount, abnormal
Prim-5 whole organism cdk2 expression increased amount, abnormal
Prim-5 whole organism cenpf expression decreased amount, abnormal
Prim-5 whole organism stag1a expression decreased amount, abnormal
Full text @ Hum. Mol. Genet.
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