Gene
stag1a
- ID
- ZDB-GENE-070912-448
- Name
- STAG1 cohesin complex component a
- Symbol
- stag1a Nomenclature History
- Previous Names
-
- stag1
- si:dkey-223d7.4 (1)
- wu:fc28h03
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable chromatin binding activity. Acts upstream of or within regulation of hematopoietic progenitor cell differentiation and regulation of vasculogenesis. Predicted to be located in chromosome, centromeric region. Predicted to be part of cohesin complex. Predicted to be active in chromatin and nucleus. Is expressed in head and trunk. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 47. Orthologous to human STAG1 (STAG1 cohesin complex component).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Ketharnathan et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
la010827Tg | Transgenic insertion | Unknown | Unknown | DNA | |
nz204 | Allele with one delins | Exon 3 | Unknown | CRISPR | |
sa12166 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa13423 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa17076 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa19759 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa25109 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-stag1a | (2) | |
MO1-stag1a | N/A | Ketharnathan et al., 2020 |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
autosomal dominant intellectual developmental disorder 47 | Alliance | Intellectual developmental disorder, autosomal dominant 47 | 617635 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Armadillo-type fold | Cohesin subunit Scc3/SA | Cohesin subunit SCC3/SA, HEAT-repeats domain | STAG | Stromalin conservative domain |
---|---|---|---|---|---|---|---|
UniProtKB:F1QNA7 | InterPro | 1258 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
stag1a-201
(1)
|
Ensembl | 3,777 nt | ||
mRNA |
stag1a-202
(1)
|
Ensembl | 7,677 nt | ||
mRNA |
stag1a-203
(1)
|
Ensembl | 3,792 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-223D7 | ZFIN Curated Data | |
Contains | SNP | rs3727630 | ZFIN Curated Data | |
Encodes | EST | fc28h03 |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001362340 (1) | 7614 nt | ||
Genomic | GenBank:CR786576 (1) | 202469 nt | ||
Polypeptide | UniProtKB:F1QNA7 (1) | 1258 aa |
- Labudina, A.A., Meier, M., Gimenez, G., Tatarakis, D., Ketharnathan, S., Mackie, B., Schilling, T.F., Antony, J., Horsfield, J.A. (2024) Cohesin composition and dosage independently affect early development in zebrafish. Development (Cambridge, England). 151(15):
- Ketharnathan, S., Labudina, A., Horsfield, J.A. (2020) Cohesin Components Stag1 and Stag2 Differentially Influence Haematopoietic Mesoderm Development in Zebrafish Embryos. Frontiers in cell and developmental biology. 8:617545
- Kasap, M., Rajani, V., Rajani, J., Dwyer, D.S. (2018) Surprising conservation of schizophrenia risk genes in lower organisms reflects their essential function and the evolution of genetic liability. Schizophrenia research. 202:120-128
- Yao, L., Chen, J., Wu, X., Jia, S., Meng, A. (2017) Zebrafish cdc6 hypomorphic mutation causes Meier-Gorlin syndrome-like phenotype. Human molecular genetics. 26(21):4168-4180
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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