ZFIN ID: ZDB-FIG-180620-41
Leacock et al., 2018 - Structure/Function Studies of the α4 Subunit Reveal Evolutionary Loss of a GlyR Subtype Involved in Startle and Escape Responses. Frontiers in molecular neuroscience   11:23 Full text @ Front. Mol. Neurosci.
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Knockdown Reagent:
Observed In:
Stage: Long-pec

Fig. 9

Embryos injected with α4a-SMO1 and the α4aR278Q mutant embryos fail to exhibit correct escape behavior. (A) Wild-type (control) fish responds to touch by with a C-bend, a turn away from the stimulus and rapid swimming. However, embryos injected with α4a-SMO1 (B) or with mRNA for the GlyR α4aR278Q subunit (C) respond more slowly, and have a pronounced head retraction—similar to a localized beo-like contraction (arrow). Single images were extracted from high-speed movies of α4a-SMO1 morphants and embryos injected with GlyR α4aR278Q subunit mRNA.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
WT + MO3-glra4a standard conditions Long-pec startle response disrupted, abnormal
Long-pec thigmotaxis disrupted, abnormal
Acknowledgments:
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Mol. Neurosci.