FIGURE

Fig. 6

ID

ZDB-FIG-180619-14

Publication

Gou et al., 2018 - sox2 and sox3 cooperate to regulate otic/epibranchial placode induction in zebrafish

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Fig. 6

Interaction betweenpax8-/-andpax2a-/-during otic development. (A-C) Expression of pax2a at 12 hpf in control (A), pax2a-/- (B) and pax2a-/-; pax8-/- (C) embryos (dorsal views, anterior to the top). Staging of embryos was confirmed by myoD expression in somites. (D-F) Lateral views (anterior to left) of the otic vesicle in control (D), pax2a-/- (E) and pax2a-/-; pax8-/- (F) embryos imaged live at 26 hpf. The small otic vesicle in the pax2a-/-; pax8-/- double mutant (F) is marked with an arrow. (G-L) Dorsal views (anterior to left) showing expression of cldna (G-I) and pax2a (J-L) at 25 hpf and 23 hpf respectively in control (G, J), pax2a-/- (H, K) and pax2a-/-; pax8-/- (I, L) embryos. Arrows indicate otic expression domains. Scale bars (D-L), 50 µm.

Expression Data

Genes:	cldna myod1 pax2a
Fish:	AB pax2a^tu29a/tu29a (AB) pax2a^tu29a/tu29a; pax8^{nia03Gt/nia03Gt} (AB)
Anatomical Terms:	otic placode otic vesicle somite
Stage Range:	5-9 somites to Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	pax2a^tu29a/tu29a (AB) pax2a^tu29a/tu29a; pax8^{nia03Gt/nia03Gt} (AB)
Observed In:	otic placode otic vesicle
Stage Range:	5-9 somites to Prim-5

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 435(1), Gou, Y., Guo, J., Maulding, K., Riley, B.B., sox2 and sox3 cooperate to regulate otic/epibranchial placode induction in zebrafish, 84-95, Copyright (2018) with permission from Elsevier. Full text @ Dev. Biol.