FIGURE

Fig. S3

ID

ZDB-FIG-180517-10

Publication

Eimon et al., 2018 - Brain activity patterns in high-throughput electrophysiology screen predict both drug efficacies and side effects

Other Figures

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Fig. S3

Visible phenotypes in the scn1lab^sa16474 line. (Top) Lateral and dorsal views of an sa16474 homozygous mutant and an age-matched sibling control larva at 7 dpf. Mutant larvae exhibit dark coloration due to dispersed melanosomes and fail to inflate their swim bladders. (Bottom) Lateral view of an sa16474 homozygous mutant and an age-matched sibling control larva shown at the same magnification at 15 dpf. Mutants fail to thrive and show elevated levels of mortality beginning in the second week of development (survival of mutants at 14 dpf=32%, n=28; survival of siblings at 14 dpf=95%, n=39).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	scn1lab^{sa16474/sa16474}
Observed In:	melanocyte swim bladder whole organism
Stage Range:	Days 7-13 to Days 14-20

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Nat. Commun.