FIGURE

Fig. 5

ID

ZDB-FIG-180426-9

Publication

McGurk et al., 2017 - In vivo zebrafish morphogenesis shows Cyp26b1 promotes tendon condensation and musculoskeletal patterning in the embryonic jaw

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Fig. 5

Loss of Cyp26b1 function disrupts cranial tendon differentiation. (A-B) Tsp4b (green) is enriched at the muscle attachment sites in wild-type zebrafish at 4 and 5 dpf. (C) At 4 dpf, cyp26b1 mutants display Tsp4b at jaw muscle attachments, though weakly at the mandibulohyoid junction (arrowheads in A’,C’) and sternohyoideus tendons (arrows in A’,C’). (D) At 5 dpf, punctate deposits of Tsp4b can be seen at all ectopic points of jaw muscle attachment. All images ventral view, anterior to the left. Scale bar = 50 μm.

Expression Data

Genes:	mCherry thbs4b
Antibody:	Ab3-thbs4b
Fish:	au101Tg; y1Tg cyp26b1^b1024/b1024; au101Tg; y1Tg
Anatomical Terms:	hyohyoideus hyoid muscle tendon cell interhyoideus mandibular muscle tendon cell ventral intermandibularis anterior ventral intermandibularis posterior (all 6)
Stage Range:	Day 4 to Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	au101Tg; y1Tg
Observed In:	hyoid muscle tendon formation mandibular muscle tendon formation
Stage Range:	Day 4 to Day 5

Phenotype Detail

Acknowledgments

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