FIGURE

Fig. 6

ID
ZDB-FIG-180410-45
Publication
Sun et al., 2017 - Proximal Tubular Expression Patterns of Megalin and Cubilin in Proteinuric Nephropathies
Other Figures
(all 6)
All Figure Page
Back to All Figure Page
Fig. 6

Proteinuric zebrafish model. (A) Phenotype of control (larvae injected with control MO) and nphs2 morphants at 4 days postfertilization (dpf). Nphs2 morphants develop severe late-stage pericardial edema at 4 dpf, often indicating glomerular injury of pronephros. (B) Ultrastructural alteration of 4-dpf zebrafish glomerular podocytes. (a) Controls show fine and regular podocyte foot processes (arrowheads); (b) nphs2 morphants display extensive and irregular podocyte foot processes (arrowheads). Bar (A) = 1 mm, (B) = 500 nm. C, capillary lumen; G, glomerular basement membrane; MO, morpholino antisense oligo.
Expression Data

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Knockdown Reagent:
Observed In:
Stage: Day 4

Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Kidney Int Rep
Your Input Welcome
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.