FIGURE

Fig. 2

ID

ZDB-FIG-180326-5

Publication

Zeng et al., 2017 - Identify a Blood-Brain Barrier Penetrating Drug-TNB using Zebrafish Orthotopic Glioblastoma Xenograft Model

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Fig. 2

Establishment of GBM xenografts in flk:eGFP Casper zebrafish. (A,B) 200–500 GBM tumor cells (U87-RFP, U251-RFP) were intracranial implanted into 3dpf flk:eGFP Casper zebrafish and monitored by confocal microscope every 24 hours, 293T-RFP cells implantation was set as control. Areas in dotted boxes were magnified right, arrows indicating infiltrating tumor cells. (B) The survivorship curve of U87 and U251 tumor-bearing zebrafish and control 293 T injected zebrafish. (C) A high-resolution image of intracranially implanted 293t-RFP cells at 6dpf, arrows indicating the cell debris. (D) A reconstructed 3D image of a U87-GFP xenograft in the deep brain of flk:mCherry zebrafish at 6dpf, arrows indicating infiltrating tumor cells. Z-stack serial images show the depth of the GBM xenograft in zebrafish brain, arrows indicating infiltrating tumor cells.

Expression Data

Genes:	EGFP mCherry
Fish:	s843Tg zf527Tg
Condition:	cancer xenotransplantation
Anatomical Term:	vasculature
Stage Range:	Day 5 to Days 7-13

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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