Fig. 4
- ID
- ZDB-FIG-180309-12
- Publication
- Sanchez et al., 2017 - Whole Genome Sequencing-Based Mapping and Candidate Identification of Mutations from Fixed Zebrafish Tissue
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The fbxw7stl64 allele phenocopies the fbxw7vu56 allele. (A and B) stl64 mutants display more nkx2.2a+ cells in the dorsal spinal cord (SpC) relative to their WT siblings at 65 hpf. TEM analysis of the ventral (C–F) and dorsal (G–J) SpC at 8 dpf shows that fbxw7stl64 mutants have more myelinated axons in the dorsal SpC (I) and thicker myelin in both regions (F and J). (K and L) Transient morpholino (MO) knockdown of fbxw7 in WT embryos results in mbp overexpression at 65 hpf compared to control-injected siblings. Error bars are SD. ** P < 0.01, *** P < 0.001. NS, not significant. |
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Stage: | Pec-fin |
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Stage Range: | Pec-fin to Days 7-13 |