FIGURE

Fig. 2

ID

ZDB-FIG-180208-27

Publication

Pérez-López et al., 2017 - Gold-Triggered Uncaging Chemistry in Living Systems

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Fig. 2

a) Gold-triggered activation of prodrugs 4 a–c in A549 cancer cell culture. Negative controls: [Au]-resins (1 mg mL⁻¹); 4 a–c (10, 100, and 1 μm, respectively). Positive control: 5 a–c (10, 100, and 1 μm, respectively). Prodrug activation assay: [Au]-resins+4 a–c (10, 100, and 1 μm, respectively). Cell viability was measured at day 4 using PrestoBlue reagent. Error bars: ±SD from n=3. b) Bioorthogonal gold-mediated release of green fluorescent Rhodamine 110 from precursor 1 in the brain of a zebrafish. The presence of the [Au]-resin is indicated with a white arrow. Study of fluorescence intensity shows high statistical significance compared to the negative control (DMSO).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Angew. Chem. Int. Ed. Engl.