PUBLICATION
Gold-Triggered Uncaging Chemistry in Living Systems
- Authors
- Pérez-López, A.M., Rubio-Ruiz, B., Sebastián, V., Hamilton, L., Adam, C., Bray, T.L., Irusta, S., Brennan, P.M., Lloyd-Jones, G., Sieger, D., Santamaría, J., Unciti-Broceta, A.
- ID
- ZDB-PUB-170713-4
- Date
- 2017
- Source
- Angewandte Chemie (International ed. in English) 56(41): 12548-12552 (Journal)
- Registered Authors
- Sieger, Dirk
- Keywords
- Bioorthogonal, Prodrugs, fluorescent probes, gold, heterogeneous catalysis
- MeSH Terms
-
- A549 Cells
- Animals
- Antineoplastic Agents/administration & dosage*
- Antineoplastic Agents/pharmacokinetics
- Brain/metabolism
- Catalysis
- Delayed-Action Preparations/chemistry*
- Fluorescent Dyes/administration & dosage*
- Fluorescent Dyes/pharmacokinetics
- Gold/chemistry*
- Humans
- Zebrafish
- PubMed
- 28699691 Full text @ Angew. Chem. Int. Ed. Engl.
Citation
Pérez-López, A.M., Rubio-Ruiz, B., Sebastián, V., Hamilton, L., Adam, C., Bray, T.L., Irusta, S., Brennan, P.M., Lloyd-Jones, G., Sieger, D., Santamaría, J., Unciti-Broceta, A. (2017) Gold-Triggered Uncaging Chemistry in Living Systems. Angewandte Chemie (International ed. in English). 56(41):12548-12552.
Abstract
Recent advances in bioorthogonal catalysis are increasing our capacity to manipulate the fate of molecules in complex biological systems. Herein we report a novel bioorthogonal uncaging strategy that is triggered by heterogeneous gold catalysis and facilitates the activation of a structurally-diverse range of therapeutics in cancer cell culture. Furthermore, this solid supported catalytic system enabled -for the first time- the locally-controlled release of a fluorescent dye in the brain of a zebrafish, offering a novel way to modulate the activity of bioorthogonal reagents in the most fragile and complex organs.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping