ZFIN ID: ZDB-FIG-180118-44
Zabinyakov et al., 2017 - Characterization of the first knock-out aldh7a1 zebrafish model for pyridoxine-dependent epilepsy using CRISPR-Cas9 technology. PLoS One   12:e0186645 Full text @ PLoS One
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Observed In:
Stage: Protruding-mouth

Fig. 6 Metabolite measurement of alpha-AASA, P6C and PA. 3dpf zebrafish embryo lysates (n = 15) were analyzed by liquid chromatography tandem mass spectrometry for homozygous and heterozygous for 5 bp deletion aldh7a1 embryos and wild-type embryos. These show elevated levels of alpha-AASA, P6C and PA compared to wild type.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
aldh7a1zf2074/zf2074 standard conditions Protruding-mouth whole organism 1-piperideine-6-carboxylate increased amount, abnormal
Protruding-mouth whole organism allysine increased amount, abnormal
Protruding-mouth whole organism pipecolic acid increased amount, abnormal
Acknowledgments:
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS One