ZFIN Figure: Zabinyakov et al., 2017, Fig. 6

ZFIN ID: ZDB-FIG-180118-44

ZFIN ID: ZDB-FIG-180118-44

Zabinyakov et al., 2017 - Characterization of the first knock-out aldh7a1 zebrafish model for pyridoxine-dependent epilepsy using CRISPR-Cas9 technology. PLoS One 12:e0186645 Full text @ PLoS One

ADDITIONAL FIGURES

PHENOTYPE:

Fish:	aldh7a1^{zf2074/zf2074}
Observed In:	whole organism 1-piperideine-6-carboxylate whole organism allysine whole organism pipecolic acid
Stage:	Protruding-mouth

Fig. 6 Metabolite measurement of alpha-AASA, P6C and PA. 3dpf zebrafish embryo lysates (n = 15) were analyzed by liquid chromatography tandem mass spectrometry for homozygous and heterozygous for 5 bp deletion aldh7a1 embryos and wild-type embryos. These show elevated levels of alpha-AASA, P6C and PA compared to wild type.

Gene Expression Details No data available

Antibody Labeling Details No data available

Phenotype Details

Fish	Conditions	Stage	Phenotype
aldh7a1^{zf2074/zf2074}	standard conditions	Protruding-mouth	whole organism 1-piperideine-6-carboxylate increased amount, abnormal
		Protruding-mouth	whole organism allysine increased amount, abnormal
		Protruding-mouth	whole organism pipecolic acid increased amount, abnormal

Acknowledgments:
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS One