FIGURE

Fig. 1

ID

ZDB-FIG-180116-13

Publication

Quintana et al., 2017 - Functional analysis of the zebrafish ortholog of HMGCS1 reveals independent functions for cholesterol and isoprenoids in craniofacial development

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Fig. 1

Mutation of hmgcs1 causes craniofacial abnormalities.

Alcian staining was performed to visualize the developing cartilage in hmgcs1 wildtype or heterozygous (Sibling) or homozygous hmgcs1 mutant larvae (Mutant). Embryos were stained at 4 days post fertilization and manual dissection of the viscerocranium and neurocranium was performed. Viscerocranium is depicted in (A) and (B) and neurocranium is depicted in (A') and (B'). Asterisk denotes basihyal. n = 38 including 8 wildtype embryos, 6 homozygous mutants, and 24 heterozygous mutants. No significant defects were present in heterozygous carriers (S1 Fig).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	hmgcs1^vu57/vu57
Observed In:	basihyal cartilage ceratobranchial cartilage ceratohyal cartilage embryonic neurocranium morphogenesis embryonic viscerocranium morphogenesis ethmoid cartilage Meckel's cartilage parachordal cartilage (all 8)
Stage:	Day 4

Phenotype Detail

Acknowledgments

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