FIGURE

Fig. S1

ID

ZDB-FIG-171206-75

Publication

Sheets, 2017 - Excessive activation of ionotropic glutamate receptors induces apoptotic hair-cell death independent of afferent and efferent innervation

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Fig. S1

A subset of hair cells in KA- and NMDA-exposed NMs form apoptotic bodies prior to cell death.

A-B) Max projection z-stack images from live-imaging of an NM in neurog1 morphant larvae with hair cells stably expressing GCaMP3. Z-stack images were taken every 30 seconds for 2.5 hours total; 300 μM KA (A) or 300 μM NMDA (B) was applied for 50 minutes, then rinsed with E3 media which remained for the duration of imaging. White dashed outlines indicate dying hair-cells blebbing and fragmenting into apoptotic bodies.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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