FIGURE

Fig. 1

ID

ZDB-FIG-171113-25

Publication

Wu et al., 2016 - Deguelin-induced blockade of PI3K/protein kinase B/MAP kinase signaling in zebrafish and breast cancer cell lines is mediated by down-regulation of fibroblast growth factor receptor 4 activity

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Fig. 1

Growth repression and apoptosis induction caused by deguelin. (A) Morphological change in zebrafish with or without deguelin treatment. Significant growth retardation can be found in 200 and 500 nmol/L deguelin-treated group. (B) Whole-mount embryos labeled with anti-pH3 antibody to examine proliferating cells in zebrafish larvae. The numbers of pH3-positive cells decreased dramatically and rarely expressed with 200 nmol/L deguelin treatment (magnification 50×). (C) Phenotypic assessed by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining. There was a dose-dependent increase of apoptotic cells in TUNEL assay. (magnification 50×).

Expression Data

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Antibody Labeling

Phenotype Data

Phenotype Detail

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