FIGURE

Fig. 3

ID
ZDB-FIG-161027-12
Publication
Cox et al., 2016 - Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis
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Fig. 3

SepH deficient larvae are prone to oxidative stress. (A) Fluorescent detection of H2O2 (PF2 fluorescence) in WT and seph mutant larvae at 5 dpf. (Scale bar: 200 µm.) (B) Quantification of H2O2 in WT and seph mutant larvae at 5 dpf. n = 5. **P < 0.01. (C) Morphological assessment of WT and seph mutant larvae exposed to menadione (1 µM) from 3 to 5 dpf. (Scale bar: 200 µm.) (D) Quantification of phenotype (unaffected, moderate, or severe) observed following menadione (1 µM) exposure from 3 to 5 dpf. Moderately affected larvae include minor defects, such as edema and tail curling, whereas severely affected larvae include major defects, such as widespread tissue necrosis (loss of transparency).

Expression Data

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Condition:
Observed In:
Stage Range: Protruding-mouth to Day 5

Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA