FIGURE

Fig. 3

ID

ZDB-FIG-160714-13

Publication

Kawauchi et al., 2016 - Using mouse and zebrafish models to understand the etiology of developmental defects in Cornelia de Lange Syndrome

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Fig. 3

Craniofacial and neuroanatomical abnormalities in Nipbl^+/- mice. (A) Top two panels show representative reconstructions of individual scans based on micro-CT analysis of wildtype (top panel) and Nipbl^+/- (middle panel) adult mice. Dorsal, lateral, and ventral views are shown. Bottom panel shows shape distance heat maps of wildtype overlaid with mutant skulls, from the entire dataset. The degree of shape change in specific bones is shown by different colors, as indicated in the heat map at right. (B) Endocranial volume (measured from CT scans) is reduced by 25% in in Nipbl^+/- mice compared to wildtype. (C) Nissl-stained coronal sections of wildtype (+/+) and Nipbl-deficient (+/-) adult brains. MHb, medial habenular nucleus; fr, fasiculus retroflexus; mt, mammillothalamic tract; dg, dentate gyrus; cc, corpus callosum. Scale bar =1 mm. (D) Cerebellar vermal hypoplasia in Nipbl^+/- mice. Folium IX (bracket) and its ventral subfolium (arrow, asterisk) are affected. Scale bar = 500 µm. Adapted from [Kawauchi et al., 2009].

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Am J Med Genet C Semin Med Genet