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Fig. S1

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ZDB-FIG-160607-4

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Enyedi et al., 2016 - The Cell Nucleus Serves as a Mechanotransducer of Tissue Damage-Induced Inflammation

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Fig. S1

Spatiotemporal Mapping of Wound-Induced Ca²⁺ Signals and cPla₂ Translocation in Live Zebrafish, Related to Figures 1 and 2

(A) Average spatiotemporal Ca²⁺ signal profile of the indicated number of transgenic Ca²⁺ reporter larvae Tg(hsp70l: GCaMP6s-NLS-P2A-mK2-NLS) after wounding in hypotonic (left) or isotonic (right) solution.

(B) Top panels, representative confocal images showing cPla₂-mK2 localization in Tg(hsp70l:cPla₂-mK2) larvae after laser-wounding (wound margin marked by red dashed line) under hypotonic (left) or isotonic (right) conditions. Bottom panel, quantification of cPla₂-mK2 INM translocation state in the cells selected at various distances from the wound margin.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

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Reprinted from Cell, 165, Enyedi, B., Jelcic, M., Niethammer, P., The Cell Nucleus Serves as a Mechanotransducer of Tissue Damage-Induced Inflammation, 1160-1170, Copyright (2016) with permission from Elsevier. Full text @ Cell