FIGURE

Fig. 5

ID
ZDB-FIG-150609-11
Publication
Love et al., 2015 - Rest represses maturation within migrating facial branchiomotor neurons
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Fig. 5

Rest targets are inappropriately expressed in rest and pk1b mutants. In situ hybridization analysis of Rest target gene expression in Tg(islet1:GFP) embryos at 24 hpf in wild type, MZrestsbu29/sbu29, and pk1bfh122/fh122 specimens. Rest targets selected for analysis are adam23a (A–C′), snap25b (D–F′), srrm4 (G–I′), and syt4 (J–L′). We also analyzed the non-Rest target and FBMN maturation marker cmet (M–O2). All five genes are expressed in fully migrated FBMNs at 48 hpf. Upper panels show co-expression with islet1:GFP to label FBMNs, with gene expression alone shown below. At this stage (24 hpf), the selected Rest targets, as well as the maturation marker cmet, are not expressed in wild type FBMNs, but are expressed in both rest and pk1b mutant FBMNs (arrows).

Expression Data
Genes:
Fish:
Anatomical Term:
Stage: Prim-5

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Observed In:
Stage: Prim-5

Phenotype Detail
Acknowledgments
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Reprinted from Developmental Biology, 401(2), Love, C.E., Prince, V.E., Rest represses maturation within migrating facial branchiomotor neurons, 220-35, Copyright (2015) with permission from Elsevier. Full text @ Dev. Biol.