ZFIN Fish: rw0Tg

ZFIN ID: ZDB-FISH-150901-21995

ZFIN ID: ZDB-FISH-150901-21995

Fish name:	rw0Tg
Genotype:	rw0Tg
Targeting Reagent:	none

HUMAN DISEASE MODELED by rw0Tg
No data available

GENE EXPRESSION
Gene expression in rw0Tg

RNA expression

Expressed Gene	Structure	Conditions	Figures
adam23a	(not) facial nerve motor nucleus motor neuron	control	Fig. 5 from Love et al., 2015
alcama	abducens motor nucleus	standard conditions	Fig. 6 from Elsen et al., 2009
chrnb2bl	Rohon-Beard neuron	standard conditions	Fig. 9 from Welsh et al., 2009
dab1a	cranial nerve VII	standard conditions	Fig. 3 from Costagli et al., 2006
dcc	(not) floor plate hindbrain	control	Fig. 2 from Suli et al., 2006
egr2b	rhombomere 3 rhombomere 5	standard conditions	Fig. 2 from Zannino et al., 2012
epha4a	rhombomere 5	control	Fig. 2 , Fig. 5 from Mapp et al., 2011
eya1	posterior lateral line neuromast	standard conditions	Fig. 6 from Wada et al., 2008
	caudal fin neuromast posterior lateral line neuromast	amputation: caudal fin	Fig. 5 from Wada et al., 2008
gbx1	hindbrain midbrain hindbrain boundary midbrain hindbrain boundary neural keel presumptive midbrain hindbrain boundary spinal cord neural tube anterior region	standard conditions	Fig. 2 from Burroughs-Garcia et al., 2011
gjd2b	secondary motor neuron spinal cord	standard conditions	Fig. 5 from Carlisle et al., 2014
her4.1	central nervous system	standard conditions	Fig. 9 from Ohata et al., 2009
hoxa2b	rhombomere 2 rhombomere 3 rhombomere 4 rhombomere 5	standard conditions	Fig. 1 from Burroughs-Garcia et al., 2011
hoxb1a	facial nerve motor nucleus motor neuron rhombomere 4 rhombomere 5	standard conditions	Fig. 2 from Zannino et al., 2012 Fig. 5 from Rohrschneider et al., 2007
hoxb4a	rhombomere 7	standard conditions	Fig. 2 from Zannino et al., 2012
isl1a	primary motor neuron Rohon-Beard neuron	standard conditions	Fig. 9 from Ohata et al., 2009
isl2a	CaP motoneuron Rohon-Beard neuron secondary motor neuron	standard conditions	Fig. S2 from Moreno et al., 2018 Fig. 9 from Ohata et al., 2009
mbpa	glial cell posterior lateral line system	physical alteration: anatomical structure	Fig. 6 from Dufourcq et al., 2006
mdga2a	adductor hyomandibulae cranial nerve V cranial nerve VII hyohyoideus interhyoideus Mauthner neuron medial longitudinal fasciculus nucleus of the medial longitudinal fasciculus medulla oblongata RoL1 RoM1c ventral intermandibularis anterior ventral intermandibularis posterior	standard conditions	Fig. 2 from Ingold et al., 2015
met	abducens motor nucleus facial nerve motor nucleus motor neuron vagal lobe motor neuron	standard conditions	Fig. 5 from Love et al., 2015 Fig. 6 from Elsen et al., 2009
ntn1a	spinal cord	control	Fig. 2 from Suli et al., 2006
ntn1b	floor plate	control	Fig. 2 from Suli et al., 2006
nxph1	facial nerve motor nucleus motor neuron	control	Fig. 5 from Thomas-Jinu et al., 2013
pcp4a	spinal cord	standard conditions	Fig. 2 from Mione et al., 2006
prickle1a	hindbrain	standard conditions	Fig. 7 from Carreira-Barbosa et al., 2003
prickle1b	facial nerve motor nucleus motor neuron rhombomere 4 rhombomere 5	standard conditions	Fig. 5 from Rohrschneider et al., 2007
prkci	hindbrain neuroepithelial cell	control	Fig. 7 from Ohata et al., 2011
rfng	rhombomere	standard conditions	Fig. 9 from Ohata et al., 2009
scn8aa	Rohon-Beard neuron secondary motor neuron	standard conditions	Fig. 2 from Pineda et al., 2006
shha	floor plate rhombomere region	standard conditions	Fig. 1 from Sittaramane et al., 2013
snap25b	(not) facial nerve motor nucleus motor neuron	control	Fig. 5 from Love et al., 2015
srrm4	(not) facial nerve motor nucleus motor neuron	control	Fig. 5 from Love et al., 2015
st8sia2	motor neuron	standard conditions	Fig. 1 from Rieger et al., 2008
syt4	(not) facial nerve motor nucleus motor neuron	control	Fig. 5 from Love et al., 2015
vangl2	endoderm floor plate rhombomere region hindbrain neural tube mesoderm	standard conditions	Fig. 1 from Sittaramane et al., 2013
wnt1	rhombomere	standard conditions	Fig. 9 from Ohata et al., 2009

Protein expression

Antibody	Antigen Genes	Structure	Conditions	Figures
Ab1-elavl		neuron posterior lateral line ganglion	control	Fig. 6 from Hofmeister et al., 2015 Fig. 3 from Zannino et al., 2012
Ab1-gad		neuron	standard conditions	Fig. 4 from Ohata et al., 2009
AB1-SLEVgp		hindbrain ventricular zone	standard conditions	Fig. 7 from Ohata et al., 2009
ab1-epha4a		rhombomere 5	control	Fig. 1 , Fig. 6 from Love et al., 2015
Ab1-isl		motor neuron spinal cord	standard conditions	Fig. S2 from Reimer et al., 2008
Ab8-GFP		cranial nerve X epibranchial ganglion	control	Fig. 4 from Punnamoottil et al., 2008
zn-5		abducens motor nucleus brainstem and spinal white matter hindbrain commissure secondary motor neuron white matter axon	standard conditions	Fig. 2 , Fig. 3 , Fig. 5 from Gurung et al., 2018 Fig. 6 from Elsen et al., 2009 Fig. 4 from Ohata et al., 2009 Fig. 4 , Fig. 5 , Fig. 6 from Sittaramane et al., 2009 Fig. 7 from Welsh et al., 2009
zn-12		hindbrain neuroepithelial cell	standard conditions	Fig. 3 from Ohata et al., 2011
zn-8		secondary motor neuron axon	control	Fig. 5 from Moreno et al., 2018
Ab1-tuba		floor plate motile cilium lateral longitudinal fasciculus medial longitudinal fasciculus trigeminal ganglion	standard conditions	Fig. 7 from Sittaramane et al., 2013 Fig. 4 from Sittaramane et al., 2009
Ab1-prkcz		hindbrain bicellular tight junction	standard conditions	Fig. 4 from Ohata et al., 2009
Ab1-tjp1		hindbrain bicellular tight junction	standard conditions	Fig. 3 from Ohata et al., 2011 Fig. 4 from Ohata et al., 2009
Ab13-GFP	GFP	hindbrain white matter hindbrain nucleus neuron	standard conditions	Fig. 4 , Fig. 7 from Ohata et al., 2009
Ab1-mdga2a	mdga2a	adductor hyomandibulae cranial nerve V cranial nerve VII hyohyoideus interhyoideus Mauthner neuron medial longitudinal fasciculus nucleus of the medial longitudinal fasciculus medulla oblongata RoL1 RoM1c ventral intermandibularis anterior ventral intermandibularis posterior	standard conditions	Fig. 2 from Ingold et al., 2015

Reporter gene expression

Expressed Gene	Structure	Conditions	Figures
EGFP	cranial nerve III cranial nerve IV cranial nerve V cranial nerve VII cranial nerve X facial nerve motor nucleus forebrain midbrain motor nucleus of vagal nerve oculomotor nucleus spinal cord motor neuron trigeminal motor nucleus trochlear motor nucleus	standard conditions	Fig. 6 from Yanagi et al., 2019 Fig. 2 from Coffey et al., 2013
	cranial nerve III cranial nerve IV cranial nerve V cranial nerve VII cranial nerve X (not) forebrain (not) midbrain	chemical treatment: ethanol	Fig. 2 , Fig. 4 from Coffey et al., 2013
GFP	abducens motor nucleus brain motor neuron branchiomotor neuron caudal fin neuromast central nervous system cranial ganglion cranial motor neuron cranial nerve III cranial nerve IV cranial nerve V (not) cranial nerve VI cranial nerve VII cranial nerve X facial ganglion facial nerve motor nucleus glossopharyngeal ganglion hindbrain white matter hindbrain nucleus lateral line nerve axon terminus motor neuron motor nucleus of vagal nerve branchiomotor neuron neuromast neuron oculomotor nucleus opercular lateral line neuromast posterior lateral line nerve posterior lateral line neuromast axon terminus primary motor neuron rhombomere 2 branchiomotor neuron rhombomere 3 branchiomotor neuron rhombomere 4 branchiomotor neuron (not) rhombomere 5 branchiomotor neuron rhombomere 6 branchiomotor neuron rhombomere 7 branchiomotor neuron Rohon-Beard neuron secondary motor neuron spinal cord motor neuron trigeminal ganglion trigeminal motor nucleus trochlear motor nucleus vagal ganglion vagal lobe	standard conditions	86 figures from 46 publications
	branchiomotor neuron cranial motor neuron facial nerve motor nucleus lateral line nerve axon terminus motor nucleus of vagal nerve primary motor neuron trigeminal motor nucleus	chemical treatment: all-trans-retinoic acid	Fig. 7 from Sebe et al., 2017 Fig. 5 from Cox et al., 2014 Fig. 3 , Fig. 5 from Joya et al., 2014 Fig. 9 , Fig. 10 from Drummond et al., 2013
	caudal fin neuromast posterior lateral line regenerating tissue posterior lateral line nerve posterior lateral line neuromast spinal cord	physical alteration: anatomical structure	Fig. 2 from Bouzaffour et al., 2010 Fig. S1 from Reimer et al., 2008 Fig. 5 from Wada et al., 2008

PHENOTYPE
Phenotype in rw0Tg

Phenotype	Conditions	Figures
axon guidance disrupted, abnormal	chemical treatment: (S)-nicotine	Fig. 2, Fig. 3 from Welsh et al., 2009
branchiomotor neuron disorganized, abnormal	chemical treatment by environment: lead diacetate	Fig. 3 from Roy et al., 2014
establishment of apical/basal cell polarity occurrence, normal	standard conditions	Fig. 4 from Ohata et al., 2009
feeding behavior decreased occurrence, abnormal	light ablation: trigeminal motor nucleus	Fig. 4 from Allen et al., 2017
hindbrain cranial neural crest cell position, normal	standard conditions	Fig. 4 from Liu et al., 2019
motor nucleus of vagal nerve anatomical region decreased size, abnormal	chemical treatment: 4-(diethylamino)benzaldehyde	Fig. 9 from Drummond et al., 2013
motor nucleus of vagal nerve anatomical region increased size, abnormal	chemical treatment: all-trans-retinoic acid	Fig. 9 from Drummond et al., 2013
primary motor neuron axon decreased length, abnormal	chemical treatment: ethanol	Fig. 3 from Joya et al., 2014
rhombomere decreased length, abnormal	chemical treatment by environment: lead diacetate	Fig. 4 from Roy et al., 2014
somite fast muscle cell decreased size, abnormal	chemical treatment: (S)-nicotine	Fig. 2 from Welsh et al., 2009
somite slow muscle cell decreased thickness, abnormal	chemical treatment: (S)-nicotine	Fig. 3 from Welsh et al., 2009
somite slow muscle cell disorganized, abnormal	chemical treatment: (S)-nicotine	Fig. 1 from Welsh et al., 2009
somite border disorganized, abnormal	chemical treatment: (S)-nicotine	Fig. 3 from Welsh et al., 2009
trunk decreased diameter, abnormal	chemical treatment: (S)-nicotine	Fig. 1 from Welsh et al., 2009

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