Fig. 3
- ID
- ZDB-FIG-150506-46
- Publication
- Huang et al., 2014 - A Novel Zebrafish Model to Provide Mechanistic Insights into the Inflammatory Events in Carrageenan-Induced Abdominal Edema
- Other Figures
- All Figure Page
- Back to All Figure Page
The anti-edematous effects of i.p. MP in carrageenan-injected adult zebrafish. The photographic images show the gross pathology of the abdomen in the lateral view from the i.p. injection vehicle (PBS) plus i.p. injection vehicle group (A and D), the i.p. injection vehicle plus i.p. injection 1.5% carrageenan group (B and E), and the i.p. injection MP plus i.p. 1.5% carrageenan group (C and F). Images A–C were taken at 0 h after the second injection (as well as 1 h after the first injection); images D–F were taken at 24 h after the second injection (as well as 25 h after the first vehicle or MP injection). Scale bars: 5 mm (for all images). Quantification of the lateral area of abdomen induced by i.p. injection of vehicle or carrageenan in adult zebrafish using a photographic image analysis system (G). We used 1 µg MP as a positive control. MP administered by i.p. injection 1 h before carrageenan injection significantly inhibited carrageenan-induced abdominal edema. Each bar in Figure G represents the mean ± SEM of 9 adult zebrafish per group. MP: methylprednisolone. *P<0.05 compared with the i.p. vehicle plus i.p. vehicle group; #P<0.05 compared with the i.p. vehicle plus i.p. 1.5% carrageenan group. |