FIGURE

Fig. 2

ID

ZDB-FIG-150423-21

Publication

Gasanov et al., 2015 - BDNF-TrkB Axis Regulates Migration of the Lateral Line Primordium and Modulates the Maintenance of Mechanoreceptor Progenitors

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Fig. 2

Trk2b is required for coordinated migration of the primordium and lateral line axons.

Compound transgenic SqET33-mi23/SqKR21 embryos expressing GFP in the lateral line axons and KillerRed in the lateral line primordium and neuromasts. A–C—5-mm-nTrk2b-MO (0.3 pmol): A—30 hpf, B—36 hpf, C—primordium at 36 hpf; D–F—nTrk2b-morphant with the weak phenotype: D—30 hpf, E—36 hpf, F—primordium at 36 hpf; G–I—nTrk2b-morphant with the strong phenotype: G—36 hpf, H—primordium at 36 hpf, I—lateral line axons at 48 hpf. The primordium leading edges are indicated by white arrows and the termini of the lateral line nerves by blue arrows.

Expression Data

Genes:	EGFP KillerRed
Fish:	sqKR21Et; sqet33mi23AEt + MO1-ntrk2b
Knockdown Reagent:	MO1-ntrk2b
Anatomical Terms:	lateral line axon lateral line primordium neuromast
Stage Range:	Prim-15 to Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	sqKR21Et; sqet33mi23AEt + MO1-ntrk2b
Knockdown Reagent:	MO1-ntrk2b
Observed In:	posterior lateral line posterior lateral line neuromast posterior lateral line neuromast deposition posterior lateral line neuromast primordium migration posterior lateral line primordium
Stage Range:	Prim-15 to Long-pec

Phenotype Detail

Acknowledgments

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