FIGURE

Fig. 6

ID
ZDB-FIG-150413-13
Publication
Ma et al., 2015 - Jag1b is essential for patterning inner ear sensory cristae by regulating anterior morphogenetic tissue separation and preventing posterior cell death
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Fig. 6

MAPK pathway inhibition blocks the separation of the anterior and lateral cristae. (A-L′) MAPKK inhibition represses expression of p-Erk3 and E-cadherin in both jag1b+/- and jag1b-/- embryos. Arrows and arrowheads indicate staining of E-Cadherin or p-Erk3. (M-M′′) In jag1b+/- embryos, treatment with the MAPKK inhibitors CI-1040 (M′) and PD0325901 (M′′) blocks separation of the anterior and lateral cristae. (N-N′′) In jag1b-/- embryos, the MAPKK inhibitors CI-1040 (N′) and PD0325901 (N′′) block the morphological change of cells in the anterior prosensory domain. Dorsolateral views. Scale bars: 20µm. Anterior towards the left and dorsal upwards.

Expression Data
Genes:
Fish:
Condition:
Anatomical Term:
Stage: Prim-25

Expression Detail
Antibody Labeling
Phenotype Data

Phenotype Detail
Acknowledgments
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