FIGURE

Fig. 2

ID

ZDB-FIG-150312-3

Publication

Quintana et al., 2014 - Hcfc1b, a zebrafish ortholog of HCFC1, regulates craniofacial development by modulating MMACHC expression

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Fig. 2

Loss of hcfc1b causes defects in craniofacial development. (A-D) Alcian:Alizarin staining was performed to visualize the developing cartilage in non-injected controls (NI), hcfc1a morphants (hcfc1a MO), hcfc1b morphants (hcfc1b MO), or embryos co-injected with hcfc1b MO and in vitro synthesized human HCFC1 mRNA. Embryos were stained at 5 days post fertilization and manual dissection of the viscerocranium and neurocranium was performed. Neurocranium is depicted in A-D and the viscerocranium is depicted in A′-D′.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-hcfc1b + MO4-tp53
Knockdown Reagents:	MO1-hcfc1b MO4-tp53
Observed In:	ceratobranchial cartilage ceratohyal cartilage Meckel's cartilage
Stage:	Day 5

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 396(1), Quintana, A.M., Geiger, E.A., Achilly, N., Rosenblatt, D.S., Maclean, K.N., Stabler, S.P., Artinger, K.B., Appel, B., Shaikh, T.H., Hcfc1b, a zebrafish ortholog of HCFC1, regulates craniofacial development by modulating MMACHC expression, 94-106, Copyright (2014) with permission from Elsevier. Full text @ Dev. Biol.