FIGURE

Fig. 5

ID

ZDB-FIG-150224-11

Publication

Berger et al., 2014 - Loss of tropomodulin4 in the zebrafish mutant träge causes cytoplasmic rod formation and muscle weakness reminiscent of nemaline myopathy

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Fig. 5

The tmod4^trg skeletal muscle has impaired force generation. (A) Peak active force at optimal length in tmod4^trg is significantly lower than that of siblings (n=6). (B) During single-twitch contraction, the half-time (t_1/2) of contraction is similar in tmod4^trg and siblings, however, the relaxation time is significantly prolonged in tmod4^trg (n=6). (C) Length–active force curves show steeper ascending limb in tmod4^trg (red) than in siblings (blue) (n=5). Force is normalised to the maximal active force at optimal length (L_opt), and length is normalised to L_opt. Data are means ± s.e.m., **P<0.01, ***P<0.001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tmod4^pc20/pc20
Observed In:	skeletal muscle
Stage:	Day 5

Phenotype Detail

Acknowledgments

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