FIGURE

Fig. 3

ID

ZDB-FIG-140422-17

Publication

Roberts et al., 2014 - Targeted transgene integration overcomes variability of position effects in zebrafish

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Fig. 3

Reproducible Venus expression patterns upon targeted integration of EL161 enhancer construct demonstrate cis-regulatory function in the brain. (A) Brain-specific enhancer effect of a transgene inserted in different integration sites. Domains of Venus activity are specified in B. Dorsal (top) and lateral (bottom) views of the head of 3 dpf F1 transgenic larvae. Scale bar: 100 μm. (B) Domains of Venus reporter expression and their distribution among targeted (PhiC31 integrase) and randomly (Tol2 transposase) transgenic lines. IF, integrase-injected founders; IP, integrase-mediated expression patterns; TF, Tol2-injected founders; TP, Tol2-mediated expression patterns. Blue depicts expression domains overlapping with esrrga activity, whereas red colour indicates additional domains. Light blue indicates weak expression.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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