FIGURE

Fig. 4

ID

ZDB-FIG-140325-15

Publication

Wang et al., 2014 - Notch3 establishes brain vascular integrity by regulating pericyte number

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Fig. 4

notch3^fh332 mutants have a deficit of pericytes. (A-F) pdgfrb⁺ brain pericytes in wild-type (WT) and mutant fish. Arrowheads, pdgfrb⁺ pericytes in the mutant larvae; open arrowheads, reduced vessel branching in forebrain and hindbrain. All images show confocal projections of whole brains from lateral view with dorsal up and anterior to the left. (G) Quantification of pdgfrb⁺ brain pericytes at different time points during embryonic and larval development in wild-type and mutant fish (ne25 each). ^*P<0.001 by Student’s two-tailed t-test. Scale bar: 200 μm.

Expression Data

Genes:	EGFP pdgfrb
Fish:	y1Tg notch3^fh332/fh332; y1Tg
Anatomical Terms:	cranial blood vessel cranial blood vessel pericyte
Stage Range:	Long-pec to Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	notch3^fh332/fh332; y1Tg
Observed In:	cranial blood vessel pericyte
Stage Range:	Long-pec to Day 4

Phenotype Detail

Acknowledgments

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