FIGURE

Fig. 1

ID
ZDB-FIG-140319-23
Publication
Zeller et al., 1999 - The zebrafish diwanka gene controls an early step of motor growth cone migration
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Fig. 1

diwanka mutant embryos display severe motor axon defects. (A) Schematic drawing of a spinal hemisegment showing CaP, MiP and RoP neurons and their axonal projection (lateral view). (B) Cross-section through a 28 hpf embryo stained with the znp-1 antibody. Motor growth cones exit the spinal cord (black arrow) and migrate on the medial surface of the somites to the ventrally located choice point (white arrow) at the horizontal myoseptum. CaP (black arrowhead) axons continue further ventrally (white arrowhead), whereas MiP neurons form a branch to the dorsal somite (white arrowhead). Wild-type (C) and diwanka mutant (D-F) embryos at 23 hpf stained with znp-1 antibody. The common path extends between the lower end of the spinal cord (black line) and the horizontal myoseptum (white line). (C) Wild-type CaP (black arrowhead) and MiP (white arrowhead) axons have completed the common path and extended on their cell-type-specific paths. (D-F) Arrowheads points to diwanka mutant motor axons which failed to exit the spinal cord (D), stalled along the common path (black arrowhead in E), stalled at the distal end of the common path (white arrowhead), or have extended on the cell-type-specific path (F).

Expression Data
Gene:
Antibody:
Fish:
Anatomical Terms:
Stage: 26+ somites

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Observed In:
Stage: 26+ somites

Phenotype Detail
Acknowledgments
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