FIGURE

Fig. 4

ID

ZDB-FIG-140313-31

Publication

Takke et al., 1999 - her4, a zebrafish homologue of the Drosophila neurogenic gene E(spl), is a target of notch signalling

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Fig. 4

Distribution of her4 transcripts in the wild-type (A) and following injection of nic RNA. her4 transcription is activated in the neural plate (asterisks, B,C). RT-PCR analysis of target gene expression following misexpression of nic (D) and ngn1 (E). As an internal standard a fragment of the elongation factor 4a (EF) was amplified. Activation of the NOTCH pathway by misexpression of nic leads to reduction of deltaD transcription and activation of her4 transcription, whereas misexpression of ngn1 activates transcription of both deltaD and her4. (F,G) her4 in situ hybridizations following her4 and nic RNA injections. Both were processed simultaneously, under identical conditions. The density of her4 transcripts in F is much higher than in G.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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