FIGURE

Fig. 4

ID

ZDB-FIG-140213-4

Publication

Wu et al., 2014 - Mediator subunit 12 coordinates intrinsic and extrinsic control of epithalamic development

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Fig. 4

Loss of Med12 activity leads to reduction in tbx2b expression and FGF signaling activation. Compared to WT, the expression of tbx2b was decreased in med12 mutants at 14 hpf (A, A′); while the expression of flh remained unchanged (B, B′). The activation of FGF signaling was also disrupted in med12 mutants at 1 dpf as shown by Tg[dusp6:d2eGFP] transgene expression (D, D′; projection neurons labeled in red by Tg[HuC:Kaede]) and dpERK staining (E, E′), while the expression of the ligand fgf8a was unaffected (C, C′).

Expression Data

Genes:	d2EGFP fgf8a Kaede noto tbx2b
Fish:	WT med12^vu304/vu304 pt6Tg; rw0130aTg med12^vu304/vu304; pt6Tg; rw0130aTg
Anatomical Terms:	pineal complex pineal complex neuron
Stage Range:	10-13 somites to Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 385(1), Wu, S.Y., de Borsetti, N.H., Bain, E.J., Bulow, C.R., and Gamse, J.T., Mediator subunit 12 coordinates intrinsic and extrinsic control of epithalamic development, 13-22, Copyright (2014) with permission from Elsevier. Full text @ Dev. Biol.