FIGURE

Fig. 6

ID

ZDB-FIG-140114-13

Publication

Charvet et al., 2013 - Knockdown of col22a1 gene in zebrafish induces a muscular dystrophy by disruption of the myotendinous junction

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Fig. 6

Genetic interaction between col22a1 and itga7. Synergistic genetic interactions between zebrafish col22a1 (COLXXII) and itga7 (integrin α7β1) (A), lama2 (laminin α2) (B) or dag1 (dystroglycan) (C), and between lama2 and itga7 or dag1 (D), and mean frequencies of muscle detachment phenotype observed in morphants. Images show lateral views of 72 hpf embryo tail musculature stained with phalloidin-rhodamine after injection, alone or in combination, of sub-phenotypic doses of morpholinos against col22a1, itga7 (A), lama2 (B) and dag1 (C). Scale bars: 50 μm. Data are mean±s.e.m. (n=3). ^***P<0.001; ^**P<0.01.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB/TU + MO1-dag1 + MO1-lama2 AB/TU + MO1-itga7 + MO1-lama2 AB/TU + MO1-itga7 + MO2-col22a1
Knockdown Reagents:	MO1-dag1 MO1-itga7 MO1-lama2 MO2-col22a1
Observed In:	muscle attachment skeletal muscle cell vertical myoseptum
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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