FIGURE

Fig. 5

ID

ZDB-FIG-130909-14

Publication

Kim et al., 2013 - Heterozygous inactivation of tsc2 enhances tumorigenesis in p53 mutant zebrafish

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Fig. 5

Angiogenesis and increased expression of angiogenic factors in tumors from tsc2;p53 compound mutant zebrafish. (A,B) Arrowheads indicate visible blood vessels on tumors from abdomen (A) and eye (B) from p53^zdf1/zdf1 zebrafish (n=8/16). (C,D) Arrowheads indicate large and tortuous blood vessels observed in abdomen (C) and eye (D) tumors from tsc2;p53 compound mutant (n=17/25) zebrafish. Scale bars: 1 mm. (E,H) Hif1-α staining, (F,J) Hif2-α staining and (G,K) Vegf-c staining in p53^zdf1/zdf1 (E–G) and tsc2;p53 compound mutant (H–K) zebrafish. Scale bar: 100 μm.

Expression Data

Antibodies:	Ab1-epas1 Ab1-hif1a Ab2-vegfc
Fish:	tp53^zdf1/zdf1 tp53^zdf1/zdf1; tsc2^vu242/+
Anatomical Terms:	eye sarcoma trunk sarcoma
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tp53^zdf1/zdf1 tp53^zdf1/zdf1; tsc2^vu242/+
Observed In:	angiogenesis
Stage Range:	Day 6 to Adult

Phenotype Detail

Acknowledgments

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