FIGURE

Fig. 7

ID

ZDB-FIG-130808-31

Publication

Clancey et al., 2013 - Maintenance of Melanophore Morphology and Survival Is Cathepsin and vps11 Dependent in Zebrafish

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Fig. 7

Calpain and Cathepsin inhibitor, ALLM, restores normal melanophore morphology and number.

AD) Dorsal images of (7dpf) wildtype or vps11^w66 larvae treated with 0.1% EtOH (A, C) or 10 μM ALLM (B, D) from 37dpf. Wildtype melanophore morphology remains unchanged, while vps11^w66 melanophores appear more uniform and less fragmented following ALLM treatment. E) Quantification of melanophores (dorsal and lateral stripes) in wildtype (AB) and vps11^w66 control or ALLM treated larvae. Note: two way ANOVA indicates a significant interaction between genotype and ALLM treatment (p<0.0001). Additionally, Bonferonni multiple comparison analysis examining effects of treatment within genotype groups suggests a significant increase in vps11^w66 melanophores following ALLM treatment (p<0.0001***). Error bars are standard deviation.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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