FIGURE

Fig. 2

ID

ZDB-FIG-130719-13

Publication

Neal et al., 2013 - H. pylori Virulence Factor CagA Increases Intestinal Cell Proliferation by Wnt Pathway Activation in a Transgenic Zebrafish Model

Other Figures

All Figure Page

Back to All Figure Page

Fig. 2

CagA expression causes overproliferation of the intestinal epithelium. (A,B) H&E stained sagittal sections of wild-type (A) and b-cagA transgenic (B) zebrafish intestine at 6 dpf. (C,D) H&E stained sagittal sections of wild-type (C) and b-cagA transgenic (D) zebrafish intestine at 15 dpf. (E,F) Intestinal epithelial cell proliferation at 6 dpf (E) and 15 dpf (F). Bars represent proliferation (mean ± s.e.m.) as a percentage of wild-type; n=10, *P<0.05 using one-way ANOVA with Tukey’s test. (G,H) Total intestinal epithelial cell counts of single H&E stained midline sagittal sections at 6 dpf (G) and 15 dpf (H). (I,J) TUNEL-positive cells in the intestinal epithelium at 6 dpf (I) and 15 dpf (J). Scale bars: 10 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	b1231Tg b1232Tg b1233Tg
Observed In:	epithelial cell proliferation intestinal epithelial cell
Stage Range:	Day 6 to Days 14-20

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dis. Model. Mech.