FIGURE

Fig. S2

ID

ZDB-FIG-130507-12

Publication

Basten et al., 2013 - Mutations in LRRC50 Predispose Zebrafish and Humans to Seminomas

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Fig. S2

Non-TGCT zebrafish lrrc50^Hu255h tumors and female gonad. (A) One fish was identified bearing a large tumor (merge of two images) located proximal to the brain, histologically resembling zebrafish malignant peripheral nerve sheath tumors (zMPNST). Albeit a rare finding in lrrc50^Hu255h zebrafish, these tumors typically do not occur in wild-type zebrafish and might therefore potentially represent an alternative lrrc50 associated tumor type. Scale bars; 50 μm. (B) We identified a tumor of somatic tissue (undetermined pathology, putative zMPNST) located in the testes of one zebrafish, unlike all other TGCTs described in this manuscript. Scale bars; 50 μm. (C) Heterozygote lrrc50 females (n = 11) do not show gonadal abnormalities; ovaries were isolated simultaneously with male testes/TGCT at an age of 30 months. Scale bars; 50 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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