FIGURE

Fig. 5

ID

ZDB-FIG-130322-25

Publication

Fitzmaurice et al., 2013 - Aldehyde dehydrogenase inhibition as a pathogenic mechanism in Parkinson disease

Other Figures

Fig. 5

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Fig. 5

Aminergic neuronal damage in Danio rerio embryos exposed to benomyl. Representative confocal images of zebrafish embryos (A, C, and E) unexposed or (B, D, and F) bathed in 1 μM benomyl from 5 h until 120 h postfertilization are shown. (G) Neuronal counts (A and B) decreased in VMAT2⁺ anterior and diencephalic clusters of ETvmat2:GFP zebrafish exposed to benomyl (solid bars) but were unaffected in (C and D) Rohon-Beard and (E and F) trigeminal neurons in Tg(isl1[ss]:Gal4-VP16,UAS:EGFP)^zf154 zebrafish. (H) Measurement of total fluorescence yielded similar results. Data are expressed as percent relative to vehicle controls (0.01% DMSO). *P < 0.1, **P < 0.05. De, diencephalon; LC, locus coeruleus; OB, olfactory bulb; Te, telencephalon.

Expression Data

Gene:	EGFP
Fish:	pku2Et zf154Tg
Condition:	chemical treatment: pharmaceutical
Anatomical Terms:	cranial nerve V diencephalon dopaminergic neuron olfactory bulb adrenergic neuron olfactory bulb dopaminergic neuron olfactory bulb serotonergic neuron Rohon-Beard neuron telencephalon adrenergic neuron telencephalon dopaminergic neuron telencephalon serotonergic neuron
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	pku2Et
Condition:	chemical treatment: pharmaceutical
Observed In:	diencephalon dopaminergic neuron olfactory bulb dopaminergic neuron
Stage:	Day 5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA