ZFIN Fish: pku2Et

ZFIN ID: ZDB-FISH-150901-14862

Fish name:	pku2Et
Genotype:	pku2Et
Targeting Reagent:	none

HUMAN DISEASE MODELED by pku2Et
No data available

GENE EXPRESSION
Gene expression in pku2Et

RNA expression

Expressed Gene	Structure	Conditions	Figures
gal	hypothalamus anterior region	control	Fig. 8 from Chen et al., 2017
	hypothalamus anterior region	heat shock	Fig. 8 from Chen et al., 2017
prokr1b	locus coeruleus norepinephrine secreting cell medulla oblongata norepinephrine secreting cell	standard conditions	Fig. 7 from Chen et al., 2017
th	diencephalon pretectum	chemical treatment: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine	Fig. 5 from Wen et al., 2008
th2	diencephalon paraventricular organ preoptic area	standard conditions	Fig. 1 from Ren et al., 2013

Protein expression

Antibody	Antigen Genes	Structure	Conditions	Figures
Ab3-th		caudal hypothalamic zone neuron caudal tuberculum neuron intermediate hypothalamus neuron preoptic area neuron pretectum neuron ventral telencephalon neuron ventral thalamus neuron	standard conditions	Fig. S5 from Mu et al., 2012
ab1-DA		caudal hypothalamic zone neuron	standard conditions	Fig. 7 from Mu et al., 2012

Reporter gene expression

Expressed Gene	Structure	Conditions	Figures
EGFP	caudal hypothalamic zone caudal tuberculum neuron diencephalon intermediate hypothalamus locus coeruleus norepinephrine secreting cell medulla oblongata norepinephrine secreting cell olfactory bulb dopaminergic neuron paraventricular organ raphe nucleus telencephalon neuron	standard conditions	Fig. 2 from Du et al., 2018 Fig. 7 from Chen et al., 2017 Fig. 1 from Lulla et al., 2016 Fig. 1 from Lu et al., 2015 Fig. 5 from Fitzmaurice et al., 2013 Fig. 1, Fig. 5 from Ren et al., 2013
	caudal tuberculum neuron diencephalon dopaminergic neuron locus coeruleus neuron olfactory bulb dopaminergic neuron paraventricular organ neuron raphe nucleus telencephalon serotonergic neuron	chemical treatment: pharmaceutical	Fig. 1 from Lulla et al., 2016 Fig. 1 from Lu et al., 2015 Fig. 5 from Fitzmaurice et al., 2013
GFP	caudal hypothalamic zone neuron caudal tuberculum neuron central nervous system diencephalon intermediate hypothalamus neuron locus coeruleus medulla oblongata neuron paraventricular organ peripheral nervous system preoptic area neuron pretectum neuron raphe nucleus telencephalon ventral telencephalon neuron ventral thalamus neuron	standard conditions	Fig. 7 , Fig. S5 , Fig. S6 from Mu et al., 2012 Fig. 2 , Fig. 4 , Fig. 6 from Wen et al., 2008
	caudal tuberculum hypothalamus locus coeruleus medulla oblongata paraventricular organ pretectum raphe nucleus telencephalon	chemical treatment: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine	Fig. 5 , Fig. 6 from Wen et al., 2008

PHENOTYPE
Phenotype in pku2Et

Phenotype	Conditions	Figures
diencephalon dopaminergic neuron decreased amount, abnormal	chemical treatment by environment: ziram	Fig. 1 from Lulla et al., 2016
diencephalon dopaminergic neuron decreased amount, abnormal	chemical treatment: pharmaceutical	Fig. 5 from Fitzmaurice et al., 2013
diencephalon neuron decreased amount, abnormal	chemical treatment by environment: ziram	Fig. 1, Fig. 6 from Lulla et al., 2016
dopaminergic neuron decreased amount, abnormal	chemical treatment: pharmaceutical	Fig. 1 from Lu et al., 2015
hypothalamus anterior region gal expression increased amount, abnormal	heat shock	Fig. 8 from Chen et al., 2017
locomotory behavior occurrence, abnormal	heat shock	Fig. 8 , Fig. S7 from Chen et al., 2017
olfactory bulb dopaminergic neuron decreased amount, abnormal	chemical treatment: pharmaceutical	Fig. 5 from Fitzmaurice et al., 2013
sleep occurrence, abnormal	heat shock	Fig. 8 , Fig. S7 from Chen et al., 2017
telencephalon dopaminergic neuron decreased amount, abnormal	chemical treatment by environment: ziram	Fig. 1 from Lulla et al., 2016
telencephalon neuron decreased amount, abnormal	chemical treatment by environment: ziram	Fig. 1, Fig. 6 from Lulla et al., 2016

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