FIGURE

Fig. 1

ID

ZDB-FIG-130318-4

Publication

Eisa-Beygi et al., 2013 - The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) pathway regulates developmental cerebral-vascular stability via prenylation-dependent signalling pathway

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Fig. 1

Pharmacological inhibition of the HMGCR pathway induces cerebral-vascular defects in developing zebrafish. (A) Representative schematic diagram of a 28 hpf zebrafish embryo, with the blue boxed area denoting the forebrain and the pink boxed area showing the midbrain regions. Scale bar=200 μm. ((B)–(G)) Representative photomicrographs of Tg(fli1:EGFP);(gata-1:DsRed) embryos soaked in DMSO or 0.5 mg/L ATV and imaged at 28 hpf. Abbreviations: PMBC, primordial midbrain channel; MCeV, middle cerebral vein; PPrA, primitive prosencephalic artery. White arrows indicate the abnormally dilated vessels in the forebrain and midbrain, whereas the black arrow denotes area of stagnant erythrocyte accumulation in the head. Scale bar=40 μm.

Expression Data

Gene:	EGFP
Fish:	sd2Tg; y1Tg
Condition:	chemical treatment: drug
Anatomical Terms:	mid cerebral vein primordial midbrain channel
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	sd2Tg; y1Tg
Condition:	chemical treatment: drug
Observed In:	blood circulation head nucleate erythrocyte primitive prosencephalic artery primordial midbrain channel
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 373(2), Eisa-Beygi, S., Hatch, G., Noble, S., Ekker, M., and Moon, T.W., The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) pathway regulates developmental cerebral-vascular stability via prenylation-dependent signalling pathway, 258-266, Copyright (2013) with permission from Elsevier. Full text @ Dev. Biol.