ZFIN ID: ZDB-FIG-130110-6
Pereboom et al., 2011 - A zebrafish model of dyskeratosis congenita reveals hematopoetic stem cell formation failure due to ribosomal protein-mediated p53 stabilization. Blood   118(20):5458-65 Full text @ Blood
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Genes:
Fish:
Anatomical Terms:
Stage Range: Prim-25 to Day 4
PHENOTYPE:
Fish:
Observed In:
Stage: Prim-25

Fig. 5 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details
Gene Antibody Fish Conditions Stage Qualifier Anatomy Assay
hbbe1.1 WT control Prim-25 nucleate erythrocyte ISH
nop10hi2578Tg/hi2578Tg standard conditions Prim-25 nucleate erythrocyte ISH
mybl2a WT control Prim-25 dorsal aorta hematopoietic stem cell ISH
nop10hi2578Tg/hi2578Tg standard conditions Prim-25 Not Detected dorsal aorta hematopoietic stem cell ISH
tp53zdf1/zdf1 standard conditions Prim-25 dorsal aorta hematopoietic stem cell ISH
tp53zdf1; nop10hi2578Tg standard conditions Prim-25 dorsal aorta hematopoietic stem cell ISH
rag1 WT control Day 4 T cell ISH
nop10hi2578Tg/hi2578Tg standard conditions Day 4 Not Detected T cell ISH
runx1 WT control Prim-25 dorsal aorta hematopoietic stem cell ISH
nop10hi2578Tg/hi2578Tg standard conditions Prim-25 Not Detected dorsal aorta hematopoietic stem cell ISH
tp53zdf1/zdf1 standard conditions Prim-25 dorsal aorta hematopoietic stem cell ISH
tp53zdf1; nop10hi2578Tg standard conditions Prim-25 dorsal aorta hematopoietic stem cell ISH
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
nop10hi2578Tg/hi2578Tg standard conditions Prim-25 dorsal aorta hematopoietic stem cell decreased amount, abnormal
Prim-25 nucleate erythrocyte decreased amount, abnormal
Prim-25 primitive hemopoiesis disrupted, abnormal
tp53zdf1; nop10hi2578Tg control Prim-25 nucleate erythrocyte normal amount, normal
Full text @ Blood