FIGURE

Fig. 3

ID

ZDB-FIG-121214-13

Publication

Li et al., 2012 - SUMO1-activating enzyme subunit 1 is essential for the survival of hematopoietic stem/progenitor cells in zebrafish

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Fig. 3

tango^hkz5 mutation causes an increased apoptosis and a decreased proliferation of HSPCs. (A-F) Double immunostaining of CD41-eGFP and TUNEL reveals a slight increase of apoptosis of CD41-eGFP⁺ cells in the CHT of 3 dpf tango^hkz5^/^hkz5 mutant zebrafish embryos. Arrows show the CD41-eGFP⁺ and TUNEL⁺ cells. (G-L) Double immunostaining of CD41-eGFP and BrdU shows a reduced proliferation of CD41-eGFP⁺ cells in the CHT of 3 dpf tango^hkz5^/^hkz5 mutant embryos. (M) Quantification of the percentage of TUNEL⁺ cells in the 3 dpf CD41-eGFP⁺ cell populations. (N) Quantification of the percentage of BrdU⁺ cells in the 3 dpf CD41-eGFP⁺ population. Error bars represent s.e.m.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	sae1^hkz5/hkz5; la2Tg
Observed In:	cell population proliferation definitive hemopoiesis programmed cell death
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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