FIGURE

Fig. 7

ID

ZDB-FIG-120725-28

Publication

Wythe et al., 2011 - Hadp1, a newly identified pleckstrin homology domain protein, is required for cardiac contractility in zebrafish

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Fig. 7

Ca²⁺ transient duration is altered following loss of hadp1. (A-H) Optical mapping and quantification of Ca²⁺ transients in the embryonic zebrafish heart. (A) Representative images of the mean Ca²⁺ transient amplitude following optical mapping, using the ratiometric dye Fura-2, in control and hadp1 morphant hearts. The red box denotes an example of the pixel areas that were sampled for quantification of ventricular transients. The far-right scale indicates the transient amplitude intensity. (B) Representative traces of Ca²⁺ transients from single sites in the atrium and ventricle of control (black) and hadp1 morphants (red). (C-E) Quantification of the atrial diastolic Ca²⁺ (C), transient amplitude (D) and transient duration (E). (F-H) Quantification of the ventricular diastolic Ca²⁺ (F), transient amplitude (G) and transient duration (H).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-plekha7a
Knockdown Reagent:	MO1-plekha7a
Observed In:	regulation of cardiac muscle contraction by calcium ion signaling
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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