FIGURE

Fig. 7

ID

ZDB-FIG-120508-74

Publication

Tadjuidje et al., 2012 - The EYA Tyrosine Phosphatase Activity Is Pro-Angiogenic and Is Inhibited by Benzbromarone

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Fig. 7

EYA inhibitors attenuate sprouting angiogenesis.

(a) Representative images of aortic rings treated with either the vector control (0.1% DMSO) or 5 μM of compounds 1, 1a, or 1b. Rings were stained with isolectin. 1c is used as a negative control as it does not inhibit EYA. (b) Quantitation of the number of sprouts per ring is included; each bar represents the mean of 6 rings. p-values from a one-way ANOVA are shown; ns is not significant, * p<0.05, ** p<0.01, *** p<0.001. (c) Compounds 1, 1a, and 1b in the indicated doses were used in aortic ring experiments. The number of sprouts per ring is plotted indicating that inhibition of aortic sprouting was dose-dependent.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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