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Fig. 7
EYA inhibitors attenuate sprouting angiogenesis.
(a) Representative images of aortic rings treated with either the vector control (0.1% DMSO) or 5 μM of compounds 1, 1a, or 1b. Rings were stained with isolectin. 1c is used as a negative control as it does not inhibit EYA. (b) Quantitation of the number of sprouts per ring is included; each bar represents the mean of 6 rings. p-values from a one-way ANOVA are shown; ns is not significant, * p<0.05, ** p<0.01, *** p<0.001. (c) Compounds 1, 1a, and 1b in the indicated doses were used in aortic ring experiments. The number of sprouts per ring is plotted indicating that inhibition of aortic sprouting was dose-dependent.