FIGURE

Fig. 1

ID

ZDB-FIG-120507-3

Publication

Eauclaire et al., 2012 - Mutations in vacuolar H(+)-ATPase subunits lead to biliary developmental defects in zebrafish

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Fig. 1

Novel mutants with abnormal PED-6 uptake. (A–D) Left lateral views of live 5 dpf wild-type (A, wt), pekin (B, pn), rouen (C, rou), and cayuga (D, cay) larvae. pn demonstrates global hypopigmentation, underutilized yolk (y), absent swim bladder and some brain edema. (E–H) Right lateral views of the same 5 dpf larvae after PED-6 uptake, demonstrating normal intensity of the gallbladder in wt (E, white arrow), but absent gallbladders in the mutants (F–H, white arrows).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	atp6ap2^p250/p250 (AB/TU) cay^p252/p252 (AB/TU) rou^p251/p251 (AB/TU)
Observed In:	brain eye intrahepatic bile duct development pericardium swim bladder inflation whole organism yolk
Stage:	Day 5

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 365(2), Eauclaire, S.F., Cui, S., Ma, L., Matous, J., Marlow, F.L., Gupta, T., Burgess, H.A., Abrams, E.W., Kapp, L.D., Granato, M., Mullins, M.C., and Matthews, R.P., Mutations in vacuolar H(+)-ATPase subunits lead to biliary developmental defects in zebrafish, 434-444, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.