FIGURE

Fig. 5

ID

ZDB-FIG-120423-47

Publication

Boggetti et al., 2012 - NBP, a zebrafish homolog of human Kank3, is a novel Numb interactor essential for epidermal integrity and neurulation

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Fig. 5

NBP and Numbs morphants are defective in C&E movements. Panels compare NBP morphants (NBP MO) and Numbs morphants (Numbs MO) with wild-type embryos (WT). A–C show dorsal view, anterior up. D shows flat preparations, anterior to the left. (A) ntla, 80% epiboly stage. Arrow indicates the notochord. (B) shhb, 90% epiboly stage. (C) myod1, six-somite stage. (D) islet1, myod1, six-somite stage. (E) Mediolateral distance (in μm) in five different positions along the anterior–posterior axis in NBP MO (open columns), Numbs MO (dotted columns) and wild-type embryos (filled columns). Scale bar: A–C = 200 μm, and D = 50 μm.

Expression Data

Genes:	myod1 shhb tbxta
Fish:	WT WT + MO1-kank3 WT + MO3-numb
Knockdown Reagents:	MO1-kank3 MO3-numb
Anatomical Terms:	axial chorda mesoderm presumptive floor plate somite
Stage Range:	75%-epiboly to 5-9 somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-kank3 WT + MO3-numb
Knockdown Reagents:	MO1-kank3 MO3-numb
Observed In:	convergent extension involved in gastrulation somitogenesis
Stage Range:	75%-epiboly to 5-9 somites

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 365(1), Boggetti, B., Jasik, J., Takamiya, M., Strähle, U., Reugels, A.M., and Campos-Ortega, J.A., NBP, a zebrafish homolog of human Kank3, is a novel Numb interactor essential for epidermal integrity and neurulation, 164-174, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.